CDMO Services

Our viral vector and cell therapy manufacturing platforms have been designed to streamline the CMC development cycle by optimizing biological components, processes and documentation to maximize titers, minimize impurities, and mitigate technical and regulatory risks.

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Our Service at a Glance

 

Translating basic operating procedures into robust, reproducible, scalable manufacturing processes

Cell Line Development

  • Clonal selection and growth parameters

  • Adaption to suspension-based growth

  • Media screening and cell culture optimization

  • Cell banking

2

Process Development

  • Vector rescue & development

  • Plasmid transfection efficiencies

  • Bioreactor parameter optimization

  • Improved product profiles

  • Streamlined scale-up & transfer to GMP production

3

Assay Development

  • Method transfer, development & optimization

  • Phase-appropriate validation & transfer to QC testing lab

  • Development of GMP grade bill of materials and raw materials testing program

4

GMP Production

  • Full utilization of single-use technologies

  • Suspension or adherent processes

  • Production up to 500L scale

  • Purification utilizing large-scale filtration and chromatographic unit operations

5

Product Release and Stability Testing

  • Viral particle titers

  • Infectivity assays

  • Molecular assays

  • Immunoassays

  • Sterility analyses

  • ICH stability chambers

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Let's Work Together

Contact Matica Bio now to request a quote and discuss your virus production needs with one of our experts. Understanding vector type, timelines and budgets early in the process will help to formulate a winning manufacturing strategy. Contact us today!