MANUFACTURING SOLUTIONS FOR ADVANCED THERAPIES
WHO WE ARE
Matica Biotechnology, Inc. is a contract development and manufacturing organization (CDMO) specializing in the production of virus-based cell & gene therapeutics, oncolytic vectors and vaccines for our clients. Supported by our parent company, CHA Biotech, our new GMP facility in College Station, TX provides comprehensive support for your virus products including:
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GMP Production in Suspension and Microcarrier Platforms
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QC Release and Stability Testing
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Process Development and Scale-up
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Assay Development and Phase-appropriate Validation
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Cell and Virus Banking
Our LENTIVIRUS and AAV manufacturing platforms have been designed to streamline the CMC development cycle by optimizing biological components, processes and documentation to maximize titers, minimize impurities, and mitigate technical and regulatory risks.
To provide our clients with world-class innovative manufacturing solutions designed to accelerate the delivery of advanced cell and gene therapies from idea to patient.
MISSION
We are establishing a global multi-facility network purpose-built for the production of cell- and virus-vectored therapies and vaccines.
Our technical platforms and manufacturing operations will be designed to stream-line the development and manufacturing cycles to support the biopharmaceutical industry’s need for faster delivery of viral vectors without sacrificing quality or safety.
VISION
OUR SERVICES
Our experts work hand-in-hand with your team guiding your project from technology transfer through to production and release of the final product. Throughout the lifetime of your program, a dedicated Project Manager is assigned to manage each activity step by step.
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Clonal selection and growth parameters
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adaptation to suspension-based growth
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Media screening and cell culture optimization
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Cell banking
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Clonal selection and growth parameters
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Adaption to suspension-based growth
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Media screening and cell culture optimization
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Cell banking
CELL LINE
DEVELOPMENT
for client-provided cell lines
PROCESS
DEVELOPMENT
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Vector rescue & development
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Plasmid transfection efficiencies
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Bioreactor parameter optimization
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Improved product profiles
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Streamlined scale-up & transfer to GMP production
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ASSAY DEVELOPMENT
& VALIDATION
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Method transfer, development & optimization
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Phase-appropriate validation & transfer to QC testing lab
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Development of GMP grade bill of materials and raw materials testing program
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GMP
PRODUCTION
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Full utilization of single-use technologies
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Suspension-based production at <50L and 500L scale
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Purification utilizing large-scale filtration and chromatographic unit operations
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PRODUCT RELEASE
& STABILITY TESTING
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Viral particle titers
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Infectivity assays
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Molecular assays
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Immunoassays
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Sterility analyses
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ICH stability chambers
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MANUFACTURING CYCLE
Technology Transfer
To transfer current process protocols and data (if any) to begin assessment and development of your project.
To establish development & manufacturing plan.
INPUT
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Client Supplied Process Information
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Biological Starting Materials
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Matica Bio Platform
DELIVERABLES
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Confirmed SOW
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Project Gantt Chart
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Tech Transfer Protocols
MANAGEMENT
President & CEO
Chief Manufacturing Officer
Chief Technical Officer
Chief Commercial Officer
Sr Director of
Quality & Regulatory Affairs
Advisor
Founder & Advisor
Founder & Advisor
NEWS
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NEWS | 03.2021
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Matica Biotechnology, Inc.
Announces Master Research Agreement with Texas A&M
NEWS | 02.2021
