WHO WE ARE
Matica Biotechnology, Inc. is a contract development and manufacturing organization (CDMO) specializing in the production of virus-based cell & gene therapeutics, oncolytic vectors and vaccines for our clients. Supported by our parent company, CHA Biotech, our new GMP facility in College Station, TX provides comprehensive support for your virus products including:
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GMP production in suspension platforms
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QC Release and Stability Testing
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Process Development and Scale-up
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Assay Development and Phase-appropriate Validation
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Cell and Virus Banking
Our LENTIVIRUS and AAV manufacturing platforms have been designed to streamline the CMC development cycle by optimizing biological components, processes and documentation to maximize titers, minimize impurities, and mitigate technical and regulatory risks.
Our Mission
To provide our clients with world-class innovative manufacturing solutions designed to accelerate the delivery of advanced cell and gene therapies from idea to patient.
Our Vision
Matica Bio is establishing a global multi-facility network purpose-built for the production of cell- and virus-vectored therapies and vaccines. Our technical platforms and manufacturing operations will be designed to stream-line the development and manufacturing cycles to support the biopharmaceutical industry’s need for faster delivery of viral vectors without sacrificing quality or safety.
PRODUCT DEVELOPMENT LIFECYCLE
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Viral particle titers
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Infectivity assays
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Molecular assays
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Immunoassays
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Sterility analyses
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ICH stability chambers
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Viral particle titers
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Infectivity assays
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Molecular assays
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Immunoassays
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Sterility analyses
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ICH stability chambers
PRODUCT RELEASE AND STABILITY TESTING
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Method transfer, development and optimization
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Phase-appropriate validation & transfer to QC testing lab
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Development of GMP grade bill of materials and raw materials testing program
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Method transfer, development and optimization
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Phase-appropriate validation & transfer to QC testing lab
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Development of GMP grade bill of materials and raw materials testing program
ASSAY DEVELOPMENT
& VALIDATION
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Vector rescue and development
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Plasmid transfection efficiencies
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Bioreactor parameter optimization
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Improved product recovery and impurity profiles
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Streamlined scale-up & transfer to GMP production
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Vector rescue and development
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Plasmid transfection efficiencies
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Bioreactor parameter optimization
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Improved product recovery and impurity profiles
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Streamlined scale-up & transfer to GMP production
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PROCESS DEVELOPMENT
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Clonal selection and growth parameters
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Adaptation to suspension-based growth
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Media screening and cell culture optimization
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Cell banking
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Clonal selection and growth parameters
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Adaptation to suspension-based growth
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Media screening and cell culture optimization
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Cell banking
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CELL LINE DEVELOPMENT FOR CLIENT-PROVIDED LINES
