[UPCOMING EVENT]

Matica Biotechnology is attending Wet AMD & DME Drug Development Summit (April 13 - 15, 2021)

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MANUFACTURING SOLUTIONS FOR ADVANCED THERAPIES

WHO WE ARE

Matica Biotechnology, Inc. is a contract development and manufacturing organization (CDMO) specializing in the production of virus-based cell & gene therapeutics, oncolytic vectors and vaccines for our clients. Supported by our parent company, CHA Biotech, our new GMP facility in College Station, TX provides comprehensive support for your virus products including:

GMP production in suspension platforms
QC Release and Stability Testing
Process Development and Scale-up
Assay Development and Phase-appropriate Validation
Cell and Virus Banking

Our LENTIVIRUS and AAV manufacturing platforms have been designed to streamline the CMC development cycle by optimizing biological components, processes and documentation to maximize titers, minimize impurities, and mitigate technical and regulatory risks.

To provide our clients with world-class innovative manufacturing solutions designed to accelerate the delivery of advanced cell and gene therapies from idea to patient.

MISSION

We are establishing a global multi-facility network purpose-built for the production of cell- and virus-vectored therapies and vaccines.

Our technical platforms and manufacturing operations will be designed to stream-line the development and manufacturing cycles to support the biopharmaceutical industry’s need for faster delivery of viral vectors without sacrificing quality or safety.

VISION

OUR SERVICES

Our experts work hand-in-hand with your team guiding your project from technology transfer through to production and release of the final product. Throughout the lifetime of your program, a dedicated Project Manager is assigned to manage each activity step by step.

Clonal selection and growth parameters
adaptation to suspension-based growth
Media screening and cell culture optimization
Cell banking

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Clonal selection and growth parameters
Adaption to suspension-based growth
Media screening and cell culture optimization
Cell banking

CELL LINE

DEVELOPMENT

for client-provided cell lines

PROCESS

DEVELOPMENT

Vector rescue&development
Plasmid transfection efficiencies
Bioreactor parameter optimization
Improved product profiles
Streamlined scale-up & transfer to GMP production

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ASSAY DEVELOPMENT

& VALIDATION

Method transfer, development & optimization
Phase-appropriate validation & transfer to QC testing lab
Development of GMP grade bill of materials and raw materials testing program

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GMP

PRODUCTION

Full utilization of single-use technologies
Suspension-based production at <50L and 500L scale
Purification utilizing large-scale filtration and chromatographic unit operations