MANUFACTURING SOLUTIONS FOR ADVANCED THERAPIES

 

WHO WE ARE

Matica Biotechnology, Inc. is a contract development and manufacturing organization (CDMO) specializing in the production of virus-based cell & gene therapeutics, oncolytic vectors and vaccines for our clients. Supported by our parent company, CHA Biotech, our new GMP facility in College Station, TX provides comprehensive support for your virus products including:

  • GMP production in suspension platforms

  • QC Release and Stability Testing

  • Process Development and Scale-up

  • Assay Development and Phase-appropriate Validation

  • Cell and Virus Banking

Our LENTIVIRUS and AAV manufacturing platforms have been designed to streamline the CMC development cycle by optimizing biological components, processes and documentation to maximize titers, minimize impurities, and mitigate technical and regulatory risks.

 
 

Our Mission

To provide our clients with world-class innovative manufacturing solutions designed to accelerate the delivery of advanced cell and gene therapies from idea to patient.

Our Vision

Matica Bio is establishing a global multi-facility network purpose-built for the production of cell- and virus-vectored therapies and vaccines. Our technical platforms and manufacturing operations will be designed to stream-line the development and manufacturing cycles to support the biopharmaceutical industry’s need for faster delivery of viral vectors without sacrificing quality or safety.

 

PRODUCT DEVELOPMENT LIFECYCLE

SERVICES

Utilizing Sartorius single-use, closed systems, Matica Bio has established a fully integrated virus production platform to accommodate clinical and commercial production scales from <50 L to 500 L for LENTIVIRUS and AAV vector products.

  • Full utilization of single-use technologies

  • Suspension-based production at 50 L and 200 L scale

  • Purification utilizing large-scale filtration and chromatographic unit operations

  • Full utilization of single-use technologies

  • Suspension-based production at <50 L and 500 L scale

  • Purification utilizing large-scale filtration and chromatographic unit operations

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GMP PRODUCTION

*Images by Sartorious

 
  • Viral particle titers

  • Infectivity assays

  • Molecular assays

  • Immunoassays

  • Sterility analyses

  • ICH stability chambers

  • Viral particle titers

  • Infectivity assays

  • Molecular assays

  • Immunoassays

  • Sterility analyses

  • ICH stability chambers

PRODUCT RELEASE AND STABILITY TESTING

  • Method transfer, development and optimization

  • Phase-appropriate validation & transfer to QC testing lab

  • Development of GMP grade bill of materials and raw materials testing program

  • Method transfer, development and optimization

  • Phase-appropriate validation & transfer to QC testing lab

  • Development of GMP grade bill of materials and raw materials testing program

ASSAY DEVELOPMENT

& VALIDATION

  • Vector rescue and development

  • Plasmid transfection efficiencies

  • Bioreactor parameter optimization

  • Improved product recovery and impurity profiles
     

  • Streamlined scale-up & transfer to GMP production

  • Vector rescue and development

  • Plasmid transfection efficiencies

  • Bioreactor parameter optimization

  • Improved product recovery and impurity profiles
     

  • Streamlined scale-up & transfer to GMP production

*

PROCESS DEVELOPMENT

  •  Clonal selection and growth parameters

  • Adaptation to suspension-based growth

  • Media screening and cell culture optimization

  • Cell banking 

  •  Clonal selection and growth parameters

  • Adaptation to suspension-based growth

  • Media screening and cell culture optimization

  • Cell banking 

*

CELL LINE DEVELOPMENT FOR CLIENT-PROVIDED LINES

 

MANAGEMENT

President and Chief Executive Officer

Founder and Advisor

Chief Manufacturing Officer

Chief Technical Officer

Chief Commercial Officer

Sr. Director of Quality and Regulatory Affairs

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NEWS

UPCOMING EVENT  |  01.2021

Meet us at

Biotech Showcase 2021 Digital!